HYPOTHALAMIC MENIN LOSS ASSOCIATED WITH AGING
HYPOTHALAMIC MENIN LOSS ASSOCIATED WITH AGING Cognition, bone mass, skin thickness, and lifespan are all affected by Menin's decline. Decline in the hypothalamic Menin may play a key role in aging, according to a new study published on March 16 in the open-access journal PLOS Biology by Lige Leng of Xiamen University, Xiamen, China, and colleagues. The findings reveal a previously unknown driver of physiological aging and suggest that supplementation with a simple amino acid may mitigate some age-related changes. The hypothalamus has been recognized as a critical mediator of physiological aging through increased neuroinflammatory signaling. In turn, inflammation promotes multiple age-related processes in the brain and periphery. Recently, Leng and colleagues showed that Menin, a hypothalamic protein, is a crucial inhibitor of hypothalamic neuroinflammation, leading them to ask what role Menin may play in aging. Here, they observed that the level of Menin in the hypoth...