HYPOTHALAMIC MENIN LOSS ASSOCIATED WITH AGING
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HYPOTHALAMIC MENIN LOSS ASSOCIATED WITH AGING Cognition, bone mass, skin thickness, and lifespan are all affected by Menin's decline. Decline in the hypothalamic Menin may play a key role in aging, according to a new study published on March 16 in the open-access journal PLOS Biology by Lige Leng of Xiamen University, Xiamen, China, and colleagues. The findings reveal a previously unknown driver of physiological aging and suggest that supplementation with a simple amino acid may mitigate some age-related changes. The hypothalamus has been recognized as a critical mediator of physiological aging through increased neuroinflammatory signaling. In turn, inflammation promotes multiple age-related processes in the brain and periphery. Recently, Leng and colleagues showed that Menin, a hypothalamic protein, is a crucial inhibitor of hypothalamic neuroinflammation, leading them to ask what role Menin may play in aging. Here, they observed that the level of Menin in the hypoth...