HIGH-FAT DIETS MAY INCREASE RISK OF COLORECTAL CANCER

HIGH-FAT DIETS MAY INCREASE RISK OF COLORECTAL CANCER Scientists pinpointed specific microbes and bile acids that become more prevalent in the guts of mice fed high-fat diets. The prevalence of colorectal cancer in people under the age of 50 has risen in recent decades. One suspected reason is the increasing rate of obesity and high-fat diets. Now, researchers at the Salk Institute and UC San Diego have discovered how high-fat diets can change gut bacteria and alter digestive molecules called bile acids modified by those bacteria, predisposing mice to colorectal cancer. In the study published in Cell Reports , the team found increased levels of specific gut bacteria in mice fed high-fat diets. Those gut bacteria, they showed, alter the composition of the bile acid pool in ways that cause inflammation and affect how quickly intestinal stem cells replenish. Bile acids are molecules produced by the liver and used by the gut to help digest food and a...