UNUSUAL FIBER SOURCES ARE POTENTIALLY EXCEPTIONALLY EFFECTIVE AT IMPROVING HEALTH

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UNUSUAL FIBER SOURCES ARE POTENTIALLY EXCEPTIONALLY EFFECTIVE AT IMPROVING HEALTH

Findings in mice suggest engaging the immune system with such fiber to counteract obesity.







    

Digesting a crunchy critter starts with the audible grinding of its rigid protective covering -- the exoskeleton. Unpalatable as it may sound, the hardcover might be good for the metabolism, according to a new study in mice from Washington University School of Medicine in St. Louis.

The researchers, led by Steven Van Dyken, Ph., an assistant professor of pathology & immunology, found in mice that digesting chitin, an abundant dietary fiber in insect exoskeletons and mushrooms and crustacean shells, engages the immune system. An active immune response was linked to less weight gain, reduced body fat, and resistance to obesity.

"Obesity is an epidemic," Van Dyken said. "What we put into our bodies has a profound effect on our physiology and on how we metabolize food. We're investigating ways to counteract obesity based on what we learn about how the immune system is engaged by diet."

The study was published Sept. 7 in Science.

The immune system is well known for safeguarding the body against various threats, including bacteria, viruses, allergens, and cancer. The researchers found that a particular arm of the immune system also is involved in chitin digestion. Stomach distention after chitin ingestion activates an innate immune response that triggers stomach cells to ramp up the production of enzymes, known as chitinases, that break down chitin. Of note, chitin is insoluble -- incapable of being dissolved in liquid -- and thus requires enzymes and harsh acidic conditions to digest.

Do-Hyun Kim, Ph.D., a postdoctoral research associate and first author of the study, performed the experiments in germ-free mice lacking intestinal bacteria. His results show that chitin activates immune responses in the absence of bacteria.

"We think chitin digestion mainly relies on the host's own chitinases," Van Dyken said. "The stomach cells change their enzymatic output through a process we refer to as adaptation. But it is surprising that this process is happening without microbial input, because bacteria in the gastrointestinal tract are also sources of chitinases that degrade chitin." Van Dyken noted that in mice with intestinal bacteria, dietary chitin altered the bacterial composition in the lower gastrointestinal tract, suggesting that gut bacteria also adapt to chitin-containing food after it leaves the stomach.

The research team found that the most significant impact on obesity in mice occurred when chitin activated the immune system but was not digested. Mice fed a high-fat diet also were given chitin. Some mice could not produce chitinases to break down chitin. The mice that ate chitin but couldn't break it down gained the least amount of weight, had the lowest body fat measurements, and resisted obesity, compared with mice that didn't eat chitin and with those that did but could break it down.

If the mice could break down chitin, they still benefited metabolically, but they adapted by overproducing chitinases to extract nutrients from chitin.

Van Dyken and his team plan to follow up on their findings in people to determine what could be added to human diets to help control obesity.

"We have several ways to inhibit stomach chitinases," he said. "Pairing those approaches with a chitin-containing food might have a very real metabolic benefit."

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