POSSIBLE LIFE EXTENSION WITH WELL-KNOWN DRUGS

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POSSIBLE LIFE EXTENSION WITH WELL-KNOWN DRUGS

    

New research from biologists at the USC Dornsife College of Letters, Arts, and Sciences reveals that mifepristone, a drug best known for ending early pregnancies, might also extend lifespan. The findings could pave the way for anti-aging treatments.

Mifepristone, which is also used to treat Cushing's disease and certain cancers, has caught the attention of scientists exploring ways to promote longer, healthier lives. In a study involving fruit flies, John Tower, professor of biological sciences at USC Dornsife, compared the effects of mifepristone to rapamycin. This drug has demonstrated the ability to increase the lifespan of various animals.

The study, published in the journal Fly, showed that both drugs independently extended the lifespan of fruit flies. Interestingly, combining the two drugs does not offer additional benefits and a slightly reduced lifespan, suggesting they act through the same biological pathway.

Researchers focused on mitophagy to understand how mifepristone and rapamycin might extend lifespan. Mitophagy is like a cellular "cleanup" process in which damaged or dysfunctional mitochondria—the cell's energy producers—are broken down and recycled. Impaired mitophagy has been linked to aging and age-related diseases, while increased mitophagy is believed to be a factor in rapamycin's life-extending effects.

For the first time, the researchers could noninvasively measure mitophagy in fruit flies. They found that mifepristone increased mitophagy to the same extent as rapamycin.

"The noninvasive in vivo mitophagy assay is novel, and our findings suggest that enhancing mitochondrial health could be central to how both drugs extend lifespan," Tower said.

Tower, whose previous research has shown anti-aging benefits, added that mifepristone—a drug already approved for various medical uses—can boost mitophagy, which points to its potential as an anti-aging treatment. Because it is already approved, repurposing mifepristone for anti-aging clinical trials could be faster, potentially accelerating the development of new longevity therapies.

Tower said future research will need to determine whether the effects observed in fruit flies can be replicated in humans. If so, mifepristone might provide a relatively accessible and safe way to reduce age-related cellular decline, paving the way for other therapies that enhance mitochondrial health to support longevity.

About the study

In addition to Tower, the study's authors include Gary Landis, Britta Baybutt, Shoham Das, Yijie Fan, Kate Olsen, and Karissa Yan of USC Dornsife's Department of Biology.

The study was funded by the National Institute on Aging grant R01AG057741.


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