HIGH BLOOD PRESSURE INJECTION REMEDY

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 HIGH BLOOD PRESSURE INJECTION REMEDY





A recent clinical trial led by Queen Mary University of London has found that a twice-yearly injection could make a real difference for people struggling to control their blood pressure. The study, published in JAMA, shows that administering an infusion every six months results in a significant and lasting drop in blood pressure for patients whose condition isn’t well-managed with standard treatments.

The trial, known as KARDIA-2, enrolled 663 participants from around the world, all living with high blood pressure that wasn’t responding well to their usual medications. Researchers tested a new drug called zilebesiran, given as an injection alongside patients’ regular blood pressure pills. Those who received zilebesiran saw better blood pressure control than those who stayed on standard therapy alone.

This could be a game-changer for the millions of adults affected by high blood pressure—about one in three people in the UK alone. Uncontrolled high blood pressure is a significant risk factor for heart attacks, strokes, and even death.

Dr. Manish Saxena, the study’s UK lead and a hypertension expert at Barts Health NHS Trust, highlighted the potential of this new approach: “Blood pressure control remains a big challenge worldwide and is one of the leading causes of heart disease and stroke. Our study shows zilebesiran is both effective and safe when added to commonly used blood pressure medications. What’s really exciting is the long-lasting effect—just one shot every six months could help millions better manage their condition.”

Zilebesiran works in a novel way. It uses RNA interference to block the liver’s production of angiotensinogen, a protein that influences blood vessel constriction. By cutting off this protein, blood vessels stay more relaxed, helping to lower blood pressure. The injection is given just under the skin.

What’s next? The researchers are planning a new Phase 2 study, KARDIA-3, which will look at zilebesiran’s potential for people with high blood pressure who already have, or are at high risk for, cardiovascular disease. Later this year, a much larger global trial will launch to study whether the injection can reduce heart attacks, strokes, and cardiovascular deaths.

The study received funding from Alnylam Pharmaceuticals, and Barts Health NHS Trust was a primary European site for the research.

High blood pressure remains a significant health challenge, but this new injection could be a crucial new tool in helping people take control of their health and reduce the risk of serious complications.

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