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 SEMAGLUTIDE: MUSCLE LOSS IN WOMEN






Recent research points to a lesser-known effect of semaglutide, the popular weight-loss drug: it doesn’t just shrink fat. For women and older adults, especially, there’s a catch—losing muscle along with the pounds.

The study, presented at ENDO 2025, tracked 40 adults with obesity over three months. Some took semaglutide, while others followed a structured diet and lifestyle program. Both groups lost weight, but up to 40% of the loss came from lean body mass—meaning muscle, not just fat. This effect was more pronounced in people who didn’t eat enough protein, which could actually lessen some of the drug’s benefits for blood sugar control.

Researchers found that women, older adults, and individuals with lower protein intake lost more muscle mass on semaglutide. The more muscle they lost, the less their blood sugar improved—a crucial concern if you’re taking the medication for metabolic health.

Dr. Melanie Haines, the study’s lead author, emphasized that protecting muscle is essential. “Older adults and women may be at higher risk of muscle loss on semaglutide, but boosting protein intake might help,” she says. Losing too much muscle can reduce the positive impact on blood sugar and increase the risk of frailty.

So what should you do? If you’re taking a GLP-1 drug like semaglutide, don’t just watch the number on the scale. Make sure your nutrition supports your muscle health, especially if you’re older or female. And you don’t have to do it alone: working with an expert team like Protime-Fitness can help you create an individualized plan that protects your muscles, boosts your results, and supports your long-term health. Visit ProTime-Fitness.org to get started and ensure your weight-loss journey makes you stronger, not weaker.


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