PROTIME-FITNESS HOLISTIC HEALTH AND WELLNESS

  A recipe for regenerating bioengineered hair Next stop: Clinical hair regeneration Researchers at the RIKEN Center for Biosystems Dynamics Research in Japan have discovered a recipe for continuous cyclical regeneration of cultured hair follicles from hair follicle stem cells. Scientists have been making waves in recent years by developing ways to grow various useful items in laboratories, from meat and diamonds to retinas and other organoids. At the RIKEN Center for Biosystems Dynamics Research in Japan, a team led by Takashi Tsuji has been working on ways to regenerate lost hair from stem cells. In an important step, a new study identifies a population of hair follicle stem cells in the skin and a recipe for normal cyclical regeneration in the lab. The researchers took fur and whisker cells from mice and cultured them in the laboratory with other biological "ingredients." They used 220 combinations of ingredients and found that combining a type of collagen with five factor...

  The drug ProAgio is effective against pancreatic and breast cancers. ProAgio, a drug developed by Georgia State University biology professor Zhi-Ren Liu and his team, is effective at treating pancreatic cancer and prolonging survival in mice, according to a study published in the journal Cellular and Molecular Gastroenterology and Hepatology. A second study, published in the  Journal of Experimental Medicine,  shows the drug is also effective against triple-negative breast cancer, a fast-growing and hard-to-treat type of breast cancer that carries a poor prognosis. ProAgio, created from a human protein, targets the cell surface receptor integrin? V??, expressed on cancer-associated fibroblasts. Fibroblasts are cells that generate collagen and other fibrous molecules and can be mobilized into service by a tumor, creating a thick, physical barrier known as the stroma, which protects cancer and helps it grow. The drug works by inducing apoptosis, or programmed cell death, ...

  Lipid epoxides target pain, inflammatory pathways in neurons. When modified using a process known as epoxidation, two naturally occurring lipids are converted into potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways that promote pain and inflammation, researchers report. These modified compounds, called EPO-NA5HT and EPO-NADA, have much more powerful effects than the molecules from which they are derived, regulating pain and inflammation. As reported in the journal  Nature Communications,  the study opens a new avenue of research in the effort to find alternatives to potentially addictive opioid pain killers, researchers say. The work is part of a long-term effort to understand the potential therapeutic byproducts of lipid metabolism, a largely neglected area of research, said University of Illinois Urbana-Champaign comparative biosciences professor Aditi Das, who led the study. While many people appreciate the role of dietary lipi...

  Vitamin D supplementation: Possible gain in life years combined with cost savings In recent years, three meta-analyses of clinical studies have concluded that vitamin D supplementation was associated with a reduction in the mortality rate from cancer of around 13 percent. Scientists at the German Cancer Research Center (DKFZ) have now transferred these results to the situation in Germany and calculated: If all Germans over the age of 50 were to take vitamin D supplements, up to 30,000 cancer deaths per year could possibly be avoided and more than 300,000 years of life could be gained -- also, health care costs could be saved. For several years now, scientists have been investigating the influence of an adequate supply of vitamin D on numerous diseases' prognosis. The focus is mainly on inflammatory diseases, diabetes, respiratory diseases, and cancer. Three meta-analyses of extensive clinical studies have been published in recent years on how vitamin D supply affects cancer morta...

  NEW DRUG EFFECTIVE IN REDUCING WEIGHT BY UP TO 20% According to a major global study involving UCL researchers, one third (35%) of people who took a new drug for treating obesity lost more than one-fifth (greater than or equal to 20%) of their total body weight . The findings from the large-scale international trial, published today in the New England Journal for Medicine, are being hailed as a "gamechanger" for improving the health of people with obesity and could play a major part in helping the UK to reduce the impact of diseases, such as COVID-19. The drug, semaglutide , works by hijacking the body's appetite-regulating system in the brain leading to reduced hunger and calorie intake. Rachel Batterham, Professor of Obesity, Diabetes, and Endocrinology, who leads the Centre for Obesity Research at UCL and the UCLH Centre for Weight Management, is one of the paper's principal authors, almost 2,000 people in 16 countries. Professor Batterham (UCL Medicine) said: ...

  Male sex, BMI, smoking, and depression all increase biological age. A combined score of biological aging shows stronger links with physical and mental health than individual indicators. A 'biological age' score predicts that being male, overweight, a smoker, and having depression all contribute to biological aging, a study published today in  eLife  reports. Aging can be measured in different ways. While chronological age is estimated by date of birth, scientists have developed a range of measurements to determine our biological age. These include measuring the length of telomeres (little caps on the end of our chromosomes that shorten as we grow older), chemical changes to our DNA (epigenetics), and changes to the proteins and metabolites in our bodies (proteomic and metabolomic measures). Although studies have linked these individual measurements to physical and mental health, it is unknown whether they influence each other -- or whether they have a cumulative effect ...

  Mediterranean-style diet associated with better-thinking skills in later life. People who eat a Mediterranean-style diet -- particularly one rich in green leafy vegetables and low in meat -- are more likely to stay mentally sharp in later life, a study shows. Closely adhering to a Mediterranean diet was associated with higher scores on a range of memory and thinking tests among adults in their late 70s, the research found. The study found no link, however, between the Mediterranean-style diet and better brain health. Markers of healthy brain aging -- such as more splendid grey or white matter volume or fewer white matter lesions -- did not differ between those regularly eating a Mediterranean diet and those who did not. These latest findings suggest that this primarily plant-based diet may benefit from cognitive functioning as we get older, researchers say. Researchers at the University of Edinburgh tested the thinking skills of more than 500 people aged 79 and without dementia. ...