The drug ProAgio is effective against pancreatic and breast cancers.

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The drug ProAgio is effective against pancreatic and breast cancers.






ProAgio, a drug developed by Georgia State University biology professor Zhi-Ren Liu and his team, is effective at treating pancreatic cancer and prolonging survival in mice, according to a study published in the journal Cellular and Molecular Gastroenterology and Hepatology.

A second study, published in the Journal of Experimental Medicine, shows the drug is also effective against triple-negative breast cancer, a fast-growing and hard-to-treat type of breast cancer that carries a poor prognosis.

ProAgio, created from a human protein, targets the cell surface receptor integrin? V??, expressed on cancer-associated fibroblasts. Fibroblasts are cells that generate collagen and other fibrous molecules and can be mobilized into service by a tumor, creating a thick, physical barrier known as the stroma, which protects cancer and helps it grow. The drug works by inducing apoptosis, or programmed cell death, in cancer-associated fibroblasts that express integrin? V??.

The dense fibrotic stroma is what makes pancreatic cancer, which has a five-year survival rate of just eight percent, so lethal and difficult to treat. Research shows thicker stroma is associated with lower survival and high recurrence rates among triple-negative breast cancer patients.

"All solid tumors use cancer-associated fibroblasts, but in pancreatic cancer and triple-negative breast cancer, the stroma is so dense there's often no way for conventional drugs to penetrate it and effectively treat cancer," said Liu.

The stroma also helps the tumor hide from your body's immune system. Immunotherapy, a type of treatment that uses your immune system to fight cancer, is less effective against tumors protected by a dense stroma rich in cancer-associated fibroblasts.

Cancer-associated fibroblasts promote angiogenesis or the development of new blood vessels. Angiogenesis plays an important role in cancer spread because solid tumors need a blood supply to grow. In both studies, Liu and his team show roAgio has a profound effect on tumor vasculature. In pancreatic cancer, it reopened blood vessels that had collapsed due to high extravascular stress caused by the dense stroma. In triple-negative breast cancer, the drug's anti-angiogenic activity reduced irregular, leaky angiogenic tumor vessels. In both cases, ProAgio allowed drugs to effectively reach cancer.

Liu's drug is unique in that it targets only cancer-associated fibroblasts -- a subclass of the cells actively engaged in supporting cancer -- rather than inactive fibroblasts. This reduces the side effects of the drug and increases its effectiveness.

"When you have a wound, for example, normal fibroblasts will secrete fibers to limit the damage and promote healing," said Liu. "The tumor region is basically a wound that won't heal. Quiescent fibroblasts may play a role in preventing cancer from spreading. You don't want to kill the good guys, only the bad guys."

ProAgio is licensed to ProDa BioTech, a pharmaceutical research company founded by Liu. In 2018, ProDa BioTech received $2 million from the National Cancer Institute to fund toxicology and pharmacokinetic studies that are required before moving the drug to early-stage clinical trials. Those studies have been completed. The company has submitted an Investigational New Drug (IND) Application, a request for authorization from the Food and Drug Administration to administer ProAgio to human subjects.

Once the IND is granted, Liu says the immediate next step is to begin clinical trials. The first trial, to determine patient tolerability and recommended phase II dose, will begin in early 2021 at the National Institute of Health Clinical Center in Bethesda, Md. It will be led by Christine Alewine, M.D., an oncologist at the National Cancer Institute. In late 2021, Emory University is set to begin a multi-site trial among breast cancer and pancreatic cancer patients.

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