SUGAR SUBSTITUTE MAY HARM THE BRAIN

SUGAR SUBSTITUTE MAY HARM THE BRAIN A new study from the University of Colorado Boulder is raising concerns about erythritol, a sugar substitute found in products ranging from low-carb ice cream to “sugar-free” sodas. Once marketed as a safe choice for people with obesity and diabetes, erythritol may pose unexpected dangers to brain health—even in small amounts. Researchers discovered that exposing brain blood vessel cells to levels of erythritol similar to those found in a typical sugar-free beverage resulted in several harmful changes. The treated cells produced less nitric oxide, a compound that helps keep blood vessels relaxed and open. At the same time, they made more endothelin-1, a protein that tightens blood vessels. When researchers introduced a substance that would usually trigger a clot, cells exposed to erythritol were less able to produce t-PA, a natural enzyme that helps break down clots. The cells also generated more reactive oxygen species—free radicals that can da...