DRUG REDUCES, STROKES AND HEART ATTACKS WHILE TREATING DIABETES

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DRUG REDUCES, STROKES AND HEART ATTACKS WHILE TREATING DIABETES


  


A groundbreaking diabetes drug is doing more than anyone expected. New research shows it's protecting patients from heart attacks and strokes, marking a significant leap forward in treatment options for those with type 2 diabetes and kidney problems.

Sotagliflozin is a drug that works differently from its predecessors. It is a double-action shield: It blocks two proteins (SGLT1 and SGLT2) that manage blood sugar levels, while other similar drugs only target one. This unique approach is turning heads in the medical community.

The results of a massive international study by Dr. Deepak Bhatt at Mount Sinai were striking. Over 10,000 patients participated, and those taking sotagliflozin saw their risk of heart attacks, strokes, and related deaths drop by 23 percent. That's nearly a quarter fewer life-threatening events – a difference that could mean thousands of lives saved.

"We're seeing something entirely new here," says Dr. Bhatt, who directs Mount Sinai's Fuster Heart Hospital. This dual-blocking action affects the kidneys, gut, heart, and brain. This comprehensive approach sets sotagliflozin apart from other diabetes medications.

The FDA has already approved the drug's use in patients with type 2 diabetes and kidney disease who face additional heart risks. These new findings, published in The Lancet Diabetes & Endocrinology, give doctors a powerful new tool in their arsenal. They can now offer patients a single medication that simultaneously tackles multiple serious health threats.

The implications are significant. Sotagliflozin offers a ray of hope for patients who are juggling diabetes, kidney problems, and heart disease risks. This treatment not only manages blood sugar but actively protects heart health.

(Note: The research was funded by Lexicon Pharmaceuticals, with Mount Sinai receiving funding for Dr. Bhatt's role as study chair.)

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