ACETAMINOPHEN AND AUTISM: WHAT'S THE LINK?






A central review by Harvard scientists has found that taking acetaminophen (Tylenol) during pregnancy could be linked to a higher risk of autism and ADHD in children. Autism, or autism spectrum disorder (ASD), is a developmental condition that affects how a person thinks, communicates, and interacts with others. It often leads to differences in social behavior, communication, and can come with unique strengths and challenges.

The research, published in BMC Environmental Health, pulled together data from 46 different studies worldwide. The team, led by Andrea Baccarelli at Harvard T.H. Chan School of Public Health and researchers from Mount Sinai, used a rigorous review process to examine whether exposure to acetaminophen in the womb might influence a child’s brain development. Their findings suggest that when Tylenol is used for extended periods during pregnancy, the odds of a child developing autism or ADHD go up.

Still, experts are careful not to sound the alarm too loudly. Acetaminophen is often the safest choice for treating pain and fever when you’re pregnant, and untreated high fevers can also harm a developing baby. The current advice? Use the lowest effective dose for the shortest possible time, and always check with your doctor. The U.S. Food and Drug Administration (FDA) recently echoed this advice, encouraging clinicians to be cautious about recommending acetaminophen during pregnancy, especially for long-term use.

Andrea Baccarelli, the study’s senior author, spoke with Health and Human Services Secretary Robert F. Kennedy Jr. before the FDA’s announcement, sharing his research showing “evidence of an association” between prenatal Tylenol exposure and neurodevelopmental disorders. The risk appears to be highest with heavy or prolonged use—meaning more than four weeks during pregnancy.

Baccarelli and his co-authors stress that more research is needed to prove whether acetaminophen directly causes these conditions, or if other factors are involved. For now, the best approach is moderation and close consultation with a healthcare provider.

This research was a collaboration between Harvard, Mount Sinai, UCLA, and UMass Lowell, and received support from several national health institutes.

In short: If you’re pregnant and considering Tylenol, don’t panic—but do check with your doctor, and keep use limited unless absolutely necessary. The link between acetaminophen and autism isn’t settled science yet, but caution is warranted.

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